Estimation of HIV/AIDS parameters
نویسنده
چکیده
This paper sho ws how w ell-established control system techniques can be in troduced to formulate guidelines for clinical testing and measurement of the HIV/AIDS disease for the estimation of HIV/AIDS parameters. It is assumed that the viral load and CD4+ T cell count in plasma blood are measured. The objective is to estimate all parameters in the basic three dimensional HIV/AIDS model. F or this purpose, through an observabilit y analysis, the minimal number of measurement samples for the CD4+ T cell and the viral load counts is rst obtained. The paper determines then the HIV progression stages when an estimation of all parameters is impossible. Outside these stages, the paper proposes tw o on-line estimation algorithms for all HIV parameters based on the well-known techniques of adaptive identifers and adaptive observers. Conditions for parameter convergence are discussed. Simulation results are demonstrated for the parameter estimation using adaptive observers. c 2002 IFA C
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عنوان ژورنال:
- Automatica
دوره 39 شماره
صفحات -
تاریخ انتشار 2003